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Cutaneous and laryngeal squamous cell carcinoma in mixed epidermolysis bullosa, kindler syndrome.
[kindler syndrome]
Kindler
syndrome
is
a
rare
autosomal
recessive
genodermatosis
characterized
by
trauma-induced
acral
blisters
in
infancy
and
childhood
,
photosensitivity
,
and
progressive
poikiloderma
.
Other
clinical
features
include
chronic
erosive
gingivitis
,
dysphagia
,
esophageal
and
urethral
strictures
,
ectropion
,
and
an
increased
risk
of
mucocutaneous
squamous
cell
carcinoma
.
We
describe
a
patient
with
Kindler
syndrome
associated
with
squamous
cell
carcinoma
of
the
skin
and
larynx
.
He
had
squamous
cell
carcinoma
on
his
left
knee
with
simultaneous
unresectable
laryngeal
carcinoma
at
the
age
of
43
years
.
The
squamous
cell
carcinoma
on
his
knee
was
excised
and
the
laryngeal
carcinoma
was
treated
with
radiation
therapy
.
Although
pathophysiology
of
Kindler
syndrome
and
its
frequency
of
association
with
cancer
are
still
not
fully
elucidated
,
we
speculate
that
long
-term
erosion
and
regeneration
of
mucosal
and
cutaneous
surfaces
may
have
induced
squamous
cell
carcinoma
on
the
patient
's
knee
and
larynx
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated