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Cutaneous and laryngeal squamous cell carcinoma in mixed epidermolysis bullosa, kindler syndrome.
[kindler syndrome]
Kindler
syndrome
is
a
rare
autosomal
recessive
genodermatosis
characterized
by
trauma-induced
acral
blisters
in
infancy
and
childhood
,
photosensitivity
,
and
progressive
poikiloderma
.
Other
clinical
features
include
chronic
erosive
gingivitis
,
dysphagia
,
esophageal
and
urethral
strictures
,
ectropion
,
and
an
increased
risk
of
mucocutaneous
squamous
cell
carcinoma
.
We
describe
a
patient
with
Kindler
syndrome
associated
with
squamous
cell
carcinoma
of
the
skin
and
larynx
.
He
had
squamous
cell
carcinoma
on
his
left
knee
with
simultaneous
unresectable
laryngeal
carcinoma
at
the
age
of
43
years
.
The
squamous
cell
carcinoma
on
his
knee
was
excised
and
the
laryngeal
carcinoma
was
treated
with
radiation
therapy
.
Although
pathophysiology
of
Kindler
syndrome
and
its
frequency
of
association
with
cancer
are
still
not
fully
elucidated
,
we
speculate
that
long
-term
erosion
and
regeneration
of
mucosal
and
cutaneous
surfaces
may
have
induced
squamous
cell
carcinoma
on
the
patient
's
knee
and
larynx
.
