Secrets of the cutaneous basement membrane.

[kindler syndrome]

The paper in this issue by Has and co -workers reports 15 non-Herlitz epidermolysis bullosa patients with the same single amino-acid substitution in collagen XVII , all of whom presented with clinical and pathological features resembling Kindler syndrome . Here we consider why and how a hemidesmosomal pathology can mimic a focal adhesion bond disease , both clinically and ultrastructurally .