Kallmann syndrome and paranoid schizophrenia: a rare combination.

[kallmann syndrome]

Kallmann syndrome (KS ) is a genetically heterogeneous and rare disorder characterised by the combination of hypothalamic hypogonadism and anosmia /hyposmia , a variable degree of intellectual disability and several somatic anomalies . In about one -third of the patients , mutations have been identified in at least seven different genes . Virtually no data are available about possible neuropsychiatric symptoms in KS . Here , a young adult male is described with a previous clinical diagnosis of KS and recent paranoid schizophrenia of which positive , but not negative symptoms , fully remitted upon treatment with antipsychotics . Neither genome-wide array analysis nor mutation analyses disclosed imbalances or mutations in any of presently known KS disease genes . This is the first report on a patient with KS and paranoid schizophrenia in whom extensive genetic analyses were performed . It is concluded that further studies are warranted in order to elucidate a possible increased risk for psychiatric symptoms in patients with KS .

Diseases
Validation

Diseases presenting "hypogonadism" symptom

adrenomyeloneuropathy

aniridia

aromatase deficiency

erdheim-chester disease

familial hypocalciuric hypercalcemia

kallmann syndrome

lamellar ichthyosis

x-linked adrenoleukodystrophy

This symptom has already been validated