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Kallmann syndrome and paranoid schizophrenia: a rare combination.
[kallmann syndrome]
Kallmann
syndrome
(
KS
)
is
a
genetically
heterogeneous
and
rare
disorder
characterised
by
the
combination
of
hypothalamic
hypogonadism
and
anosmia
/
hyposmia
,
a
variable
degree
of
intellectual
disability
and
several
somatic
anomalies
.
In
about
one
-
third
of
the
patients
,
mutations
have
been
identified
in
at
least
seven
different
genes
.
Virtually
no
data
are
available
about
possible
neuropsychiatric
symptoms
in
KS
.
Here
,
a
young
adult
male
is
described
with
a
previous
clinical
diagnosis
of
KS
and
recent
paranoid
schizophrenia
of
which
positive
,
but
not
negative
symptoms
,
fully
remitted
upon
treatment
with
antipsychotics
.
Neither
genome-
wide
array
analysis
nor
mutation
analyses
disclosed
imbalances
or
mutations
in
any
of
presently
known
KS
disease
genes
.
This
is
the
first
report
on
a
patient
with
KS
and
paranoid
schizophrenia
in
whom
extensive
genetic
analyses
were
performed
.
It
is
concluded
that
further
studies
are
warranted
in
order
to
elucidate
a
possible
increased
risk
for
psychiatric
symptoms
in
patients
with
KS
.
Diseases
Validation
Diseases presenting
"a variable degree of intellectual disability and several somatic anomalies"
symptom
kallmann syndrome
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