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Decreased expression of Kallmann syndrome 1 sequence gene (KAL1) contributes to oral squamous cell carcinoma progression and significantly correlates with poorly differentiated grade.
[kallmann syndrome]
Kallmann
syndrome
1
sequence
gene
(
KAL
1
)
protein
is
an
extracellular
matrix
associated
protein
which
plays
vital
roles
in
neurons
development
and
cell
migration
.
However
,
its
biological
functions
and
clinical
implications
have
yet
not
been
revealed
in
oral
carcinogenesis
.
The
objective
of
the
study
was
to
evaluate
the
role
of
KAL
1
in
oral
cancer
and
determine
clinical
significance
of
KAL
1
in
oral
squamous
cell
carcinomas
(
OSCCs
)
.
The
expression
pattern
of
KAL
1
was
examined
in
a
testing
cohort
including
OSCCs
(
n
=
42
)
and
paired
adjacent
tissues
(
PATs
)
(
n
=
14
)
by
real-time
PCR
.
The
result
was
further
validated
in
a
validating
cohort
of
OSCCs
(
n
=
32
)
.
Correlation
between
clinicopathological
parameters
and
KAL
1
mRNA
levels
was
analyzed
by
Kruskal-
Wallis
test
.
In
vitro
,
the
effects
of
KAL
1
ablation
through
siRNA-mediated
knockdown
on
the
proliferation
of
OSCC
cells
were
determined
by
CCK
-
8
,
BrdU
,
and
colonies
formation
assays
,
respectively
.
In
addition
,
cell
cycle
distribution
was
further
evaluated
by
cytometry
.
We
observed
that
remarkably
decreased
expression
of
KAL
1
mRNA
in
two
independent
cohorts
(
P
=
0
.
0002
and
P
=
0
.
033
,
respectively
)
.
Furthermore
,
downregulated
KAL
1
mRNA
was
significantly
associated
with
worse
pathological
grade
(
P
=
0
.
013
and
P
=
0
.
035
,
respectively
)
.
Upon
KAL
1
silencing
,
the
proliferation
and
colonies
formation
potentials
of
OSCC
cells
were
notably
promoted
by
accelerating
G
1
to
M
phase
transition
.
These
data
indicated
that
KAL
1
plays
a
potential
suppressive
role
on
OSCC
initiation
and
progression
,
and
KAL
1
gene
may
serve
as
an
adjuvant
biomarker
for
the
identification
of
pathological
grade
.
Diseases
Validation
Diseases presenting
"determine clinical significance of kal1 in oral squamous cell carcinomas"
symptom
kallmann syndrome
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