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Congenital polymicrogyria including the perisylvian region in early childhood.
[kabuki syndrome]
Six
pediatric
cases
including
four
infants
with
congenital
polymicrogyria
including
the
perisylvian
region
are
presented
herein
.
Their
clinical
features
were
analyzed
and
compared
with
patients
suffering
from
congenital
bilateral
perisylvian
syndrome
(
CBPS
)
.
Two
specific
abnormalities
were
diagnosed
as
accompanying
disorders
in
two
cases
,
namely
Kabuki
syndrome
and
Peters
'
anomaly
.
In
the
other
four
cases
,
the
pathogenetic
etiology
was
not
elucidated
.
Subtle
symptoms
,
such
as
choking
and
drooling
became
detectable
in
one
case
each
,
and
expressive
language
development
was
delayed
in
two
patients
.
A
developmental
delay
became
apparent
in
five
cases
during
the
follow-up
period
,
and
epilepsy
was
observed
in
one
patient
with
onset
at
12
years
of
age
.
Our
results
indicate
that
the
presence
of
perisylvian
polymicrogyria
may
not
always
result
in
the
development
of
oropharyngoglossal
dysfunction
or
dysarthria
,
although
most
patients
tend
to
gradually
show
the
onset
of
developmental
disorders
.
To
support
cognitive
and
psychosocial
development
,
an
early
integrated
approach
,
including
not
only
conventional
speech
and
language
therapy
,
but
also
various
communication
methods
is
essential
for
patients
with
congenital
polymicrogyria
including
the
perisylvian
region
.