Rare Diseases Symptoms Automatic Extraction

A Rosenthal fiber encephalomyelopathy resembling Alexander's disease in 3 sheep.

[alexander disease]

We report an encephalomyelopathy in three 18-month-old Merino sheep with features of adult-onset Alexander's disease (AD), a human primary astrocytic disorder. The signature histologic finding was the presence of numerous hypereosinophilic, intra-astrocytic inclusions (Rosenthal fibers), mainly in perivascular, subpial, and subependymal sites, especially in the caudal brain stem and spinal cord. Although AD usually results from mutations in the glial fibrillary acidic protein (GFAP) gene, no such mutation was detected in these sheep. However, the annual clinical presentation of this disorder in a few sheep in the affected flock is suggestive of a familial pattern of occurrence.

Diseases presenting "fibrillary acidic protein" symptom

  • alexander disease
  • canavan disease
  • erdheim-chester disease
  • hirschsprung disease
  • hydrocephalus with stenosis of the aqueduct of sylvius
  • von hippel-lindau disease

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