Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Laminin-332-integrin interaction: a target for cancer therapy?
[junctional epidermolysis bullosa]
For
many
years
,
extracellular
matrix
(
ECM
)
was
considered
to
function
as
a
tissue
support
and
filler
.
However
,
we
now
know
that
ECM
proteins
control
many
cellular
events
through
their
interaction
with
cell-surface
receptors
and
cytoplasmic
signaling
pathways
.
For
example
,
they
regulate
cell
proliferation
,
cell
division
,
cell
adhesion
,
cell
migration
,
and
apoptosis
.
We
focus
in
this
review
on
a
laminin
isoform
,
laminin-
332
(
formerly
termed
laminin-
5
)
,
a
major
component
of
the
basement
membrane
(
BM
)
of
skin
and
other
epithelial
tissues
.
It
is
composed
of
3
subunits
(
alpha
3
beta
3
and
gamma
3
and
interacts
with
at
least
two
integrin
receptors
expressed
by
epithelial
cells
(
alpha
3
beta
1
and
alpha
6
beta
4
integrin
.
Mutations
in
either
laminin-
332
or
integrin
alpha
6
beta
4
result
in
junctional
epidermolysis
bullosa
,
a
blistering
skin
disease
,
while
targeting
of
laminin-
332
by
autoantibodies
in
cicatricial
pemphigoid
leads
to
dysadhesion
of
epithelial
cells
from
their
underlying
connective
tissue
.
Abnormal
expression
of
laminin-
332
and
its
integrin
receptors
is
also
a
hallmark
of
certain
tumor
types
and
is
believed
to
promote
invasion
of
colon
,
breast
and
skin
cancer
cells
.
Moreover
,
there
is
emerging
evidence
that
laminin-
332
and
its
protease
degradation
products
are
not
only
found
at
the
leading
front
of
several
tumors
but
also
likely
induce
and
/
or
promote
tumor
cell
migration
.
Thus
,
in
this
review
,
we
focus
specifically
on
the
role
of
laminin-
332
and
its
integrin
receptors
in
adhesion
,
proliferation
,
and
migration
/
invasion
of
cancer
cells
.
Finally
,
we
discuss
strategies
for
the
development
of
laminin-
332
-
based
antagonists
for
the
treatment
of
malignant
tumors
.
Diseases
Validation
Diseases presenting
"abnormal expression"
symptom
benign recurrent intrahepatic cholestasis
junctional epidermolysis bullosa
pyruvate dehydrogenase deficiency
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom