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Responsiveness of nonHerlitz junctional epidermolysis bullosa to topical gentian violet.
[junctional epidermolysis bullosa]
Gentian
violet
(
GV
)
,
a
mixture
of
crystal
violet
and
methyl
violet
,
a
dye
belonging
to
the
di
-
and
triaminophenylmethanes
class
and
has
been
widely
used
for
its
bactericidal
and
fungicidal
properties
.
To
date
,
there
have
been
no
reports
of
long
-term
therapeutic
use
of
GV
in
epidermolysis
bullosa
(
EB
)
.
Two
brothers
with
nonHerlitz
junctional
epidermolysis
bullosa
(
JEB
)
aged
12
and
14
tried
topical
GV
to
one
lower
leg
with
conventional
silicone
dressings
and
this
was
compared
with
leaving
the
other
leg
with
silicone
dressings
alone
,
over
4
weeks
.
Wounds
were
photographed
and
measured
using
Visitrak
analysis
.
Pain
,
ooze
,
and
appearance
were
assessed
using
visual
analog
scales
(
VAS
)
scales
and
Quality
of
life
using
Dermatology
Life
Quality
Index
and
QOLEB
(
2
)
tools
.
The
side
treated
with
dressings
and
GV
reduced
to
14
.
9
cm
(
2
)
(
-
20
.
74
%
)
and
to
9
.
5
cm
(
2
)
(
-
56
.
62
%
)
for
dressings
alone
in
the
older
brother
(
EB-
012
)
and
to
4
.
2
cm
(
2
)
(
+
20
%
)
and
12
.
5
cm
(
2
)
(
-
7
%
)
for
the
younger
brother
(
EB-
011
)
in
ulcer
size
,
respectively
.
Both
patients
did
complain
of
stinging
on
the
sites
treated
within
a
few
days
.
QOL
measures
and
VAS
scores
did
not
show
any
significant
change
.
GV
may
be
considered
to
be
a
therapeutic
option
for
ulcers
in
nH-
JEB
patients
and
potentially
other
EB
subtypes
.
A
formal
randomized
controlled
trial
and
long
-term
safety
study
of
GV
in
EB
is
recommended
.
Diseases
Validation
Diseases presenting
"pain"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
aniridia
aromatase deficiency
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital diaphragmatic hernia
congenital toxoplasmosis
cushing syndrome
cutaneous mastocytosis
cystinuria
dedifferentiated liposarcoma
dentin dysplasia
dracunculiasis
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
familial mediterranean fever
focal myositis
hirschsprung disease
hodgkin lymphoma, classical
holt-oram syndrome
junctional epidermolysis bullosa
kabuki syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
malignant atrophic papulosis
neuralgic amyotrophy
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
phenylketonuria
pleomorphic liposarcoma
primary hyperoxaluria type 1
proteus syndrome
pyomyositis
scrub typhus
sneddon syndrome
systemic capillary leak syndrome
thoracic outlet syndrome
trochlear dysplasia
typhoid
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
wolf-hirschhorn syndrome
This symptom has already been validated
