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Responsiveness of nonHerlitz junctional epidermolysis bullosa to topical gentian violet.
[junctional epidermolysis bullosa]
Gentian
violet
(
GV
)
,
a
mixture
of
crystal
violet
and
methyl
violet
,
a
dye
belonging
to
the
di
-
and
triaminophenylmethanes
class
and
has
been
widely
used
for
its
bactericidal
and
fungicidal
properties
.
To
date
,
there
have
been
no
reports
of
long
-term
therapeutic
use
of
GV
in
epidermolysis
bullosa
(
EB
)
.
Two
brothers
with
nonHerlitz
junctional
epidermolysis
bullosa
(
JEB
)
aged
12
and
14
tried
topical
GV
to
one
lower
leg
with
conventional
silicone
dressings
and
this
was
compared
with
leaving
the
other
leg
with
silicone
dressings
alone
,
over
4
weeks
.
Wounds
were
photographed
and
measured
using
Visitrak
analysis
.
Pain
,
ooze
,
and
appearance
were
assessed
using
visual
analog
scales
(
VAS
)
scales
and
Quality
of
life
using
Dermatology
Life
Quality
Index
and
QOLEB
(
2
)
tools
.
The
side
treated
with
dressings
and
GV
reduced
to
14
.
9
cm
(
2
)
(
-
20
.
74
%
)
and
to
9
.
5
cm
(
2
)
(
-
56
.
62
%
)
for
dressings
alone
in
the
older
brother
(
EB-
012
)
and
to
4
.
2
cm
(
2
)
(
+
20
%
)
and
12
.
5
cm
(
2
)
(
-
7
%
)
for
the
younger
brother
(
EB-
011
)
in
ulcer
size
,
respectively
.
Both
patients
did
complain
of
stinging
on
the
sites
treated
within
a
few
days
.
QOL
measures
and
VAS
scores
did
not
show
any
significant
change
.
GV
may
be
considered
to
be
a
therapeutic
option
for
ulcers
in
nH-
JEB
patients
and
potentially
other
EB
subtypes
.
A
formal
randomized
controlled
trial
and
long
-term
safety
study
of
GV
in
EB
is
recommended
.
