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Diagnosis, pathogenesis and treatment of myositis: recent advances.
[inclusion body myositis]
Dermatomyositis
(
DM
)
,
polymyositis
(
PM
)
,
necrotizing
myopathy
(
NM
)
and
inclusion
body
myositis
(
IBM
)
are
four
distinct
subtypes
of
idiopathic
inflammatory
myopathies
-
in
short
myositis
.
Recent
studies
have
shed
some
light
on
the
unique
pathogenesis
of
each
entity
.
Some
of
the
clinical
features
are
distinct
,
but
muscle
biopsy
is
indispensable
for
making
a
reliable
diagnosis
.
The
use
of
magnetic
resonance
imaging
of
skeletal
muscles
and
detection
of
myositis
-
specific
autoantibodies
have
become
useful
additions
to
our
diagnostic
repertoire
.
Only
few
controlled
trials
are
available
to
substantiate
current
treatment
approaches
for
myositis
and
hopes
are
high
that
novel
modalities
will
become
available
within
the
next
few
years
.
In
this
review
we
provide
an
up-
to
-date
overview
of
the
pathogenesis
and
diagnostic
approach
of
myositis
.
We
aim
to
present
a
guide
towards
therapeutic
and
general
management
.
Diseases
Validation
Diseases presenting
"muscle biopsy"
symptom
cadasil
canavan disease
cohen syndrome
epidermolysis bullosa simplex
familial mediterranean fever
focal myositis
inclusion body myositis
neuralgic amyotrophy
pyomyositis
pyruvate dehydrogenase deficiency
sneddon syndrome
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