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Diagnosis, pathogenesis and treatment of myositis: recent advances.
[inclusion body myositis]
Dermatomyositis
(
DM
)
,
polymyositis
(
PM
)
,
necrotizing
myopathy
(
NM
)
and
inclusion
body
myositis
(
IBM
)
are
four
distinct
subtypes
of
idiopathic
inflammatory
myopathies
-
in
short
myositis
.
Recent
studies
have
shed
some
light
on
the
unique
pathogenesis
of
each
entity
.
Some
of
the
clinical
features
are
distinct
,
but
muscle
biopsy
is
indispensable
for
making
a
reliable
diagnosis
.
The
use
of
magnetic
resonance
imaging
of
skeletal
muscles
and
detection
of
myositis
-
specific
autoantibodies
have
become
useful
additions
to
our
diagnostic
repertoire
.
Only
few
controlled
trials
are
available
to
substantiate
current
treatment
approaches
for
myositis
and
hopes
are
high
that
novel
modalities
will
become
available
within
the
next
few
years
.
In
this
review
we
provide
an
up-
to
-date
overview
of
the
pathogenesis
and
diagnostic
approach
of
myositis
.
We
aim
to
present
a
guide
towards
therapeutic
and
general
management
.
