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A random Abstract
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The heart in inflammatory myopathies.
[inclusion body myositis]
Systemic
autoimmune
diseases
are
becoming
increasingly
linked
to
accelerated
risks
of
cardiovascular
disease
and
events
.
What
is
apparent
from
the
above
review
is
that
the
IIM
are
not
an
exception
to
this
growing
pattern
.
Although
not
always
clinically
apparent
,
there
seems
to
be
a
large
percentage
of
patients
who
have
subclinical
CV
involvement
.
Many
of
the
traditional
risk
factors
for
CAD
,
such
as
hypertension
and
hyperlipidemia
,
are
associated
with
developing
cardiac
involvement
in
patients
with
IIM
.
At
this
time
,
it
is
unclear
how
much
of
the
atherosclerotic
CV
morbidity
and
mortality
in
IIM
patients
is
driven
by
traditional
CV
risk
factors
versus
the
effects
of
chronic
systemic
inflammation
from
the
underlying
IIM
.
The
effects
of
immunosuppression
on
cardiac
disease
and
events
in
IIM
patients
requires
further
investigation
in
carefully
controlled
studies
.
IIM
patients
with
cardiac
involvement
are
at
increased
risk
for
overall
mortality
when
compared
with
IIM
patients
without
CV
disease
.
The
risk
of
severe
cardiac
and
vascular
disease
complications
seems
to
be
higher
than
that
of
the
general
population
.
Treatments
can
be
focused
on
preventing
traditional
cardiovascular
risk
factors
including
avoidance
of
corticosteroids
when
possible
,
although
this
task
remains
challenging
in
IIM
as
is
true
of
other
rheumatic
diseases
.
Once
complications
do
develop
,
they
should
be
managed
similarly
to
patients
without
IIM
.
The
use
of
statins
for
hyperlipidemia
and
atherosclerosis
in
IIM
is
an
area
that
is
in
need
of
further
investigation
,
although
initial
work
suggests
that
their
use
is
not
uncommon
by
IIM
specialists
.
Further
work
is
needed
to
determine
whether
aggressive
immunosuppressive
treatment
of
patients
with
subclinical
cardiac
disease
will
lead
to
better
outcomes
.
Work
is
also
needed
in
the
area
of
better
laboratory
,
imaging
,
and
serologic
testing
to
identify
patients
at
risk
for
the
worst
cardiovascular
complications
.
At
this
point
,
based
on
the
body
of
evidence
reviewed
here
and
elsewhere
,
it
is
imperative
that
physicians
treating
IIM
patients
performa
routine
cardiovascular
risk
assessment
at
the
onset
of
diagnosis
.
Appropriate
diagnostic
and
monitoring
studies
should
be
performed
on
those
patients
who
screening
history
or
examination
is
suggestive
of
cardiac
involvement
.
Diseases
Validation
Diseases presenting
"subclinical cardiac disease"
symptom
inclusion body myositis
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