Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
In vivo interaction proteomics reveal a novel p38 mitogen-activated protein kinase/Rack1 pathway regulating proteostasis in Drosophila muscle.
[inclusion body myositis]
Several
recent
studies
suggest
that
systemic
aging
in
metazoans
is
differentially
affected
by
functional
decline
in
specific
tissues
,
such
as
skeletal
muscle
.
In
Drosophila
,
longevity
appears
to
be
tightly
linked
to
myoproteostasis
,
and
the
formation
of
misfolded
protein
aggregates
is
a
hallmark
of
senescence
in
aging
muscle
.
Similarly
,
defective
myoproteostasis
is
described
as
an
important
contributor
to
the
pathology
of
several
age-related
degenerative
muscle
diseases
in
humans
,
e
.
g
.
,
inclusion
body
myositis
.
p
38
mitogen-activated
protein
kinase
(
MAPK
)
plays
a
central
role
in
a
conserved
signaling
pathway
activated
by
a
variety
of
stressful
stimuli
.
Aging
p
38
MAPK
mutant
flies
display
accelerated
motor
function
decline
,
concomitant
with
an
enhanced
accumulation
of
detergent-insoluble
protein
aggregates
in
thoracic
muscles
.
Chemical
genetic
experiments
suggest
that
p
38
-
mediated
regulation
of
myoproteostasis
is
not
limited
to
the
control
of
reactive
oxygen
species
production
or
the
protein
degradation
pathways
but
also
involves
upstream
turnover
pathways
,
e
.
g
.
,
translation
.
Using
affinity
purification
and
mass
spectrometry
,
we
identified
Rack
1
as
a
novel
substrate
of
p
38
MAPK
in
aging
muscle
and
showed
that
the
genetic
interaction
between
p
38
b
and
Rack
1
controls
muscle
aggregate
formation
,
locomotor
function
,
and
longevity
.
Biochemical
analyses
of
Rack
1
in
aging
and
stressed
muscle
suggest
a
model
whereby
p
38
MAPK
signaling
causes
a
redistribution
of
Rack
1
between
a
ribosome-bound
pool
and
a
putative
translational
repressor
complex
.
Diseases
Validation
Diseases presenting
"e"
symptom
allergic bronchopulmonary aspergillosis
aromatase deficiency
cadasil
child syndrome
dracunculiasis
gm1 gangliosidosis
inclusion body myositis
kallmann syndrome
krabbe disease
neonatal adrenoleukodystrophy
pleomorphic liposarcoma
pyomyositis
trochlear dysplasia
wolf-hirschhorn syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom