Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
In vivo interaction proteomics reveal a novel p38 mitogen-activated protein kinase/Rack1 pathway regulating proteostasis in Drosophila muscle.
[inclusion body myositis]
Several
recent
studies
suggest
that
systemic
aging
in
metazoans
is
differentially
affected
by
functional
decline
in
specific
tissues
,
such
as
skeletal
muscle
.
In
Drosophila
,
longevity
appears
to
be
tightly
linked
to
myoproteostasis
,
and
the
formation
of
misfolded
protein
aggregates
is
a
hallmark
of
senescence
in
aging
muscle
.
Similarly
,
defective
myoproteostasis
is
described
as
an
important
contributor
to
the
pathology
of
several
age-related
degenerative
muscle
diseases
in
humans
,
e
.
g
.
,
inclusion
body
myositis
.
p
38
mitogen-activated
protein
kinase
(
MAPK
)
plays
a
central
role
in
a
conserved
signaling
pathway
activated
by
a
variety
of
stressful
stimuli
.
Aging
p
38
MAPK
mutant
flies
display
accelerated
motor
function
decline
,
concomitant
with
an
enhanced
accumulation
of
detergent-insoluble
protein
aggregates
in
thoracic
muscles
.
Chemical
genetic
experiments
suggest
that
p
38
-
mediated
regulation
of
myoproteostasis
is
not
limited
to
the
control
of
reactive
oxygen
species
production
or
the
protein
degradation
pathways
but
also
involves
upstream
turnover
pathways
,
e
.
g
.
,
translation
.
Using
affinity
purification
and
mass
spectrometry
,
we
identified
Rack
1
as
a
novel
substrate
of
p
38
MAPK
in
aging
muscle
and
showed
that
the
genetic
interaction
between
p
38
b
and
Rack
1
controls
muscle
aggregate
formation
,
locomotor
function
,
and
longevity
.
Biochemical
analyses
of
Rack
1
in
aging
and
stressed
muscle
suggest
a
model
whereby
p
38
MAPK
signaling
causes
a
redistribution
of
Rack
1
between
a
ribosome-bound
pool
and
a
putative
translational
repressor
complex
.
Diseases
Validation
Diseases presenting
"motor function decline"
symptom
inclusion body myositis
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom