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[Autoantibody profile in myositis].
[inclusion body myositis]
Patients
suffering
from
muscular
symptoms
or
with
an
increase
of
creatine
kinase
levels
may
present
a
myopathy
.
In
such
situations
,
clinicians
have
to
confirm
the
existence
of
a
myopathy
and
determine
if
it
is
an
acquired
or
a
genetic
muscular
disease
.
In
the
presence
of
an
acquired
myopathy
after
having
ruled
out
an
infectious
,
a
toxic
agent
or
an
endocrine
cause
,
physicians
must
identify
which
type
of
idiopathic
myopathy
the
patient
is
presenting
:
either
a
myositis
including
polymyositis
,
dermatomyositis
,
and
inclusion
body
myositis
,
or
an
immune-mediated
necrotizing
myopathy
.
Histopathology
examination
of
a
muscle
biopsy
is
determinant
but
detection
of
autoantibody
is
now
also
crucial
.
The
myositis
-
specific
antibodies
and
myositis
-associated
antibodies
lead
to
a
serologic
approach
complementary
to
the
histological
classification
,
because
strong
associations
of
myositis
-
specific
antibodies
with
clinical
features
and
survival
have
been
documented
.
The
presence
of
anti-synthetase
antibodies
is
associated
with
an
original
histopathologic
pattern
between
polymyositis
and
dermatomyositis
,
and
defines
a
syndrome
where
interstitial
lung
disease
drives
the
prognosis
.
Anti-
MDA-
5
antibody
are
specifically
associated
with
dermatomyositis
,
and
define
a
skin
-
lung
syndrome
with
a
frequent
severe
disease
course
.
Anti-
TIF
1
-
γ
is
also
associated
with
dermatomyositis
but
its
presence
is
frequently
predictive
of
a
cancer
association
whereas
anti-
MI
2
is
associated
with
the
classical
dermatomyositis
.
Two
specific
antibodies
,
anti-
SRP
and
anti-
HMGCR
,
are
observed
in
patients
with
immune-mediated
necrotizing
myopathies
and
may
be
very
useful
to
distinguish
acquired
myopathies
from
dystrophic
muscular
diseases
in
case
of
a
slow
onset
and
to
allow
the
initiation
of
effective
therapy
.
Diseases
Validation
Diseases presenting
"an original histopathologic pattern between polymyositis"
symptom
inclusion body myositis
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