Rare Diseases Symptoms Automatic Extraction
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A random Abstract
Our Project
Our Team
Coupling poroelasticity and CFD for cerebrospinal fluid hydrodynamics.
[hydrocephalus with stenosis of the aqueduct of sylvius]
This
research
uses
a
novel
coupling
of
poroelastic
theory
and
computational
fluid
dynamics
to
investigate
acute
hydrocephalus
resulting
from
stenosis
of
the
cerebral
aqueduct
.
By
coupling
poroelastic
theory
with
a
multidimensional
simulation
of
the
cerebral
aqueduct
we
are
able
to
investigate
,
for
the
first
time
,
the
impact
of
physically
relevant
stenosis
patterns
on
ventricular
enlargement
,
accounting
for
the
nonintuitive
long
time
history
responses
of
the
ventricular
system
.
Preliminary
findings
demonstrate
clearly
the
importance
that
the
fluidic-poroelastic
coupling
plays
:
ventricular
enlargement
is
significantly
smaller
with
local
stenosis
patterns
and
almost
all
of
the
observable
pressure
drop
occurs
across
the
stenosis
.
Short
timescale
effects
[
O
(
heartbeat
)
]
are
explored
and
their
contribution
to
the
long
timescales
interrogated
.
Diseases
Validation
Diseases presenting
"hydrocephalus"
symptom
achondroplasia
alexander disease
canavan disease
congenital toxoplasmosis
harlequin ichthyosis
hirschsprung disease
homocystinuria without methylmalonic aciduria
hydrocephalus with stenosis of the aqueduct of sylvius
krabbe disease
monosomy 21
proteus syndrome
severe combined immunodeficiency
sneddon syndrome
von hippel-lindau disease
wiskott-aldrich syndrome
This symptom has already been validated