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Coupling poroelasticity and CFD for cerebrospinal fluid hydrodynamics.
[hydrocephalus with stenosis of the aqueduct of sylvius]
This
research
uses
a
novel
coupling
of
poroelastic
theory
and
computational
fluid
dynamics
to
investigate
acute
hydrocephalus
resulting
from
stenosis
of
the
cerebral
aqueduct
.
By
coupling
poroelastic
theory
with
a
multidimensional
simulation
of
the
cerebral
aqueduct
we
are
able
to
investigate
,
for
the
first
time
,
the
impact
of
physically
relevant
stenosis
patterns
on
ventricular
enlargement
,
accounting
for
the
nonintuitive
long
time
history
responses
of
the
ventricular
system
.
Preliminary
findings
demonstrate
clearly
the
importance
that
the
fluidic-poroelastic
coupling
plays
:
ventricular
enlargement
is
significantly
smaller
with
local
stenosis
patterns
and
almost
all
of
the
observable
pressure
drop
occurs
across
the
stenosis
.
Short
timescale
effects
[
O
(
heartbeat
)
]
are
explored
and
their
contribution
to
the
long
timescales
interrogated
.
Diseases
Validation
Diseases presenting
"first time"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
alpha-thalassemia
aniridia
aromatase deficiency
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
classical phenylketonuria
congenital adrenal hyperplasia
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dentin dysplasia
dentinogenesis imperfecta
dracunculiasis
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
familial mediterranean fever
gm1 gangliosidosis
harlequin ichthyosis
heparin-induced thrombocytopenia
hirschsprung disease
hodgkin lymphoma, classical
holt-oram syndrome
hydrocephalus with stenosis of the aqueduct of sylvius
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
malignant atrophic papulosis
megacystis-microcolon-intestinal hypoperistalsis syndrome
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
omenn syndrome
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
phenylketonuria
primary effusion lymphoma
primary hyperoxaluria type 1
severe combined immunodeficiency
sneddon syndrome
triple a syndrome
trochlear dysplasia
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
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