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Coupling poroelasticity and CFD for cerebrospinal fluid hydrodynamics.
[hydrocephalus with stenosis of the aqueduct of sylvius]
This
research
uses
a
novel
coupling
of
poroelastic
theory
and
computational
fluid
dynamics
to
investigate
acute
hydrocephalus
resulting
from
stenosis
of
the
cerebral
aqueduct
.
By
coupling
poroelastic
theory
with
a
multidimensional
simulation
of
the
cerebral
aqueduct
we
are
able
to
investigate
,
for
the
first
time
,
the
impact
of
physically
relevant
stenosis
patterns
on
ventricular
enlargement
,
accounting
for
the
nonintuitive
long
time
history
responses
of
the
ventricular
system
.
Preliminary
findings
demonstrate
clearly
the
importance
that
the
fluidic-poroelastic
coupling
plays
:
ventricular
enlargement
is
significantly
smaller
with
local
stenosis
patterns
and
almost
all
of
the
observable
pressure
drop
occurs
across
the
stenosis
.
Short
timescale
effects
[
O
(
heartbeat
)
]
are
explored
and
their
contribution
to
the
long
timescales
interrogated
.
Diseases
Validation
Diseases presenting
"the impact of physically relevant stenosis patterns on ventricular enlargement"
symptom
hydrocephalus with stenosis of the aqueduct of sylvius
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