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Magnetic resonance velocity mapping of 3D cerebrospinal fluid flow dynamics in hydrocephalus: preliminary results.
[hydrocephalus with stenosis of the aqueduct of sylvius]
To
investigate
the
detectability
of
CSF
flow
alterations
in
the
ventricular
system
of
patients
with
hydrocephalus
using
time-resolved
3
D
MR
velocity
mapping
.
MR
velocity
mapping
was
performed
in
21
consecutive
hydrocephalus
patients
and
21
age-matched
volunteers
using
a
3
D
phase-contrast
(
PC
)
sequence
.
Velocity
vectors
and
particle
path
lines
were
calculated
for
visualisation
of
flow
dynamics
.
CSF
flow
was
classified
as
"
hypomotile
flow
"
if
it
showed
attenuated
dynamics
and
as
"
hypermotile
flow
"
if
it
showed
increased
dynamics
compared
with
volunteers
.
Diagnostic
efficacy
was
compared
with
routine
2
D
cine
PC
-MRI
.
Seven
patients
showed
hypomotile
CSF
flow
:
six
had
non-
communicating
hydrocephalus
due
to
aqueductal
stenosis
.
One
showed
oscillating
flow
between
the
lateral
ventricles
after
craniotomy
for
intracranial
haemorrhage
.
Seven
patients
showed
normal
flow
:
six
had
hydrocephalus
ex
vacuo
due
to
brain
atrophy
.
One
patient
who
underwent
ventriculostomy
10
years
ago
showed
a
flow
path
through
the
opening
.
Seven
patients
showed
hypermotile
flow
:
three
had
normal
pressure
hydrocephalus
,
three
had
dementia
,
and
in
one
the
diagnosis
remained
unclear
.
The
diagnostic
efficacy
of
velocity
mapping
was
significantly
higher
except
for
that
of
aqueductal
stenosis
.
Our
approach
may
be
useful
for
diagnosis
,
therapy
planning
,
and
follow-up
of
different
kinds
of
hydrocephalus
.
Diseases
Validation
Diseases presenting
"hydrocephalus"
symptom
achondroplasia
alexander disease
canavan disease
congenital toxoplasmosis
harlequin ichthyosis
hirschsprung disease
homocystinuria without methylmalonic aciduria
hydrocephalus with stenosis of the aqueduct of sylvius
krabbe disease
monosomy 21
proteus syndrome
severe combined immunodeficiency
sneddon syndrome
von hippel-lindau disease
wiskott-aldrich syndrome
This symptom has already been validated