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Hodgkin lymphoma: pathology, pathogenesis, and a plethora of potential prognostic predictors.
[hodgkin lymphoma, classical]
Hodgkin
lymphoma
(
HL
)
encompasses
2
unique
clinicopathologic
entities
,
classical
Hodgkin
lymphoma
(
CHL
)
(
∼
95
%
of
cases
)
and
nodular
lymphocyte
predominant
HL
(
∼
5
%
of
cases
)
.
Both
subtypes
demonstrate
a
paucity
of
surreptitious
(
in
CHL
)
neoplastic
B
cells
within
a
background
of
reactive
inflammatory
cells
underscoring
both
the
relatedness
of
these
2
entities
to
each
other
,
as
well
as
their
distinction
from
other
types
of
lymphoid
neoplasia
.
Clinically
,
they
are
primarily
nodal
diseases
that
disseminate
in
a
predictable
manner
to
contiguous
nodal
regions
.
The
biology
of
HL
as
a
whole
,
as
well
as
the
genetic
and
pathologic
features
that
distinguish
CHL
from
nodular
lymphocyte
predominant
HL
and
other
lymphomas
has
been
the
subject
of
a
wealth
of
investigation
in
recent
decades
.
The
aim
of
this
review
is
to
detail
the
pathologic
features
of
HL
and
to
highlight
the
recent
insights
into
its
molecular
basis
and
the
myriad
prognostic
markers
being
described
.
