Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma.
[hodgkin lymphoma, classical]
Cannabinoid
receptor
1
(
CB
1
)
is
expressed
in
certain
types
of
malignancies
.
An
analysis
of
CB
1
expression
and
function
in
Hodgkin
lymphoma
(
HL
)
,
one
of
the
most
frequent
lymphomas
,
was
not
performed
to
date
.
We
examined
the
distribution
of
CB
1
protein
in
primary
cases
of
HL
.
Using
lymphoma
derived
cell
lines
,
the
role
of
CB
1
signaling
on
cell
survival
was
investigated
.
A
predominant
expression
of
CB
1
was
found
in
Hodgkin-
Reed
-
Sternberg
cells
in
a
vast
majority
of
classical
HL
cases
.
The
HL
cell
lines
L
428
,
L
540
and
KM-H
2
showed
strong
CB
1
-
abundance
and
displayed
a
dose-dependent
decline
of
viability
under
CB
1
inhibition
with
AM
251
.
Further
,
application
of
AM
251
led
to
decrease
of
constitutively
active
NFκB
/
p
65
,
a
crucial
survival
factor
of
HRS-cells
,
and
was
followed
by
elevation
of
apoptotic
markers
in
HL
cells
.
T
he
present
study
identifies
CB
1
as
a
feature
of
HL
,
which
might
serve
as
a
potential
selective
target
in
the
treatment
of
Hodgkin
lymphoma
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated