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The prognostic value of interim positron emission tomography scan in patients with classical Hodgkin lymphoma.
[hodgkin lymphoma, classical]
The
prognostic
value
of
interim
positron
emission
tomography
(
PET
)
was
evaluated
after
2
cycles
of
doxorubicin
,
bleomycin
,
vinblastin
and
dacarbazine
in
classical
Hodgkin
lymphoma
patients
(
n
=
229
)
,
based
on
Deauville
criteria
.
In
early
stage
non-bulky
disease
,
bulky
stage
II
disease
,
advanced
stage
low
International
Prognostic
Score
(
IPS
≤
2
)
and
advanced
stage
(
IPS
≥
3
)
,
3
-
year
progression-free
survival
rates
in
PET
2
-
negative
vs
.
PET
2
-
positive
groups
were
95
·
9
%
vs
.
76
·
9
%
(
P
<
0
·
0018
)
,
83
·
3
%
vs
.
20
·
0
%
(
P
=
0
·
017
)
,
77
·
0
%
vs
.
30
·
0
%
(
P
<
0
·
001
)
and
71
·
0
%
vs
.
44
·
4
%
(
P
=
0
·
155
)
,
respectively
.
The
outcome
after
positive
PET
2
was
better
than
previously
reported
.
The
results
from
non-randomized
studies
of
PET
2
-
guided
therapy
would
be
valuable
with
careful
interpretation
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated