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Epstein-Barr virus and Hodgkin lymphoma in Jordan.
[hodgkin lymphoma, classical]
This
study
aims
to
examine
the
possible
association
of
Epstein-
Barr
virus
(
EBV
)
in
Classical
Hodgkin
lymphoma
(
cHL
)
and
to
shed
light
on
the
epidemiology
of
Hodgkin
lymphoma
(
HL
)
in
Jordan
.
We
examined
100
consecutive
cases
of
HL
for
the
presence
of
EBV
in
tumor
cells
by
immunohistochemistry
for
latent
membrane
protein-
1
(
LMP-
1
)
.
We
collected
patient
data
on
age
,
sex
and
histologic
subtype
.
We
reviewed
the
pathological
findings
in
each
case
and
confirmed
diagnosis
.
Nodular
lymphocyte
predominant
HL
was
diagnosed
in
6
%
of
the
cases
and
these
were
negative
for
EBV
LMP-
1
.
Of
the
94
cases
of
cHL
,
65
%
were
males
,
the
most
common
subtype
was
nodular
sclerosis
(
NS
)
,
representing
70
%
of
the
cases
,
and
45
.
7
%
of
cHL
(
43
%
of
all
HL
)
cases
were
positive
for
EBV
LMP-
1
.
The
positive
cases
were
significantly
related
to
age
:
⩽
15
years
and
>
51
years
(
p
:
0
.
009
and
0
.
014
respectively
)
,
male
gender
(
p
:
0
.
03
)
and
mixed
cellularity
(
MC
)
subtype
(
p
:
<
0
.
0001
)
.
In
line
with
other
developing
countries
,
there
also
appears
to
be
a
trend
towards
a
decreasing
association
of
EBV
with
cHL
and
a
subtype
switch
from
MC
to
NS
in
Jordan
.
T
he
epidemiology
of
HL
in
Jordan
and
some
developing
countries
is
approaching
that
of
developed
countries
.
Diseases
Validation
Diseases presenting
"common subtype"
symptom
carcinoma of the gallbladder
cutaneous mastocytosis
hodgkin lymphoma, classical
krabbe disease
pleomorphic liposarcoma
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