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A random Abstract
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Current status of prognostication in classical Hodgkin lymphoma.
[hodgkin lymphoma, classical]
Classical
Hodgkin
lymphoma
(
cHL
)
is
characterized
by
a
paucity
of
neoplastic
Hodgkin
/
Reed
Sternberg
(
HRS
)
cells
within
a
complex
cellular
milieu
that
is
rendered
immunologically
incapable
of
reacting
against
CD
30
(
+
)
HRS
cells
due
to
a
plethora
of
immune
escape
mechanisms
initiated
by
the
neoplastic
cells
.
Accounting
for
25
%
of
all
lymphomas
and
nearly
95
%
of
all
Hodgkin
lymphomas
,
patients
with
cHL
are
typically
young
adults
.
Besides
traditional
prognostic
factors
,
such
as
the
International
Prognostic
Index
(
IPI
)
,
newer
imaging
and
ancillary
biomarkers
(
CD
68
,
Galectin-
1
and
plasma
microRNA
)
have
shown
promise
.
Furthermore
,
the
evolution
of
gene
expression
profiling
(
GEP
)
in
recent
years
has
enabled
the
development
of
several
practically
feasible
GEP-based
predictors
with
prognostic
relevance
.
This
review
discusses
the
current
status
of
clinical
prognostication
in
cHL
,
the
critical
role
of
histological
evaluation
in
light
of
several
mimicking
entities
,
and
the
relevance
of
tissue
as
well
as
serum
biomarkers
pertaining
to
immune
escape
mechanisms
and
recent
GEP
studies
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated