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EBV may be expressed in the LP cells of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) in both children and adults.
[hodgkin lymphoma, classical]
Nodular
lymphocyte-predominant
Hodgkin
lymphoma
(
NLPHL
)
and
classical
Hodgkin
lymphoma
(
CHL
)
are
classified
separately
because
of
their
distinct
clinical
and
pathologic
features
.
Whereas
Epstein-
Barr
virus
(
EBV
)
is
detected
in
the
neoplastic
cells
of
25
%
to
70
%
of
CHL
,
NLPHL
is
generally
considered
to
be
EBV
(
-
)
.
We
assessed
EBV
status
in
302
pediatric
and
adult
cases
of
NLPHL
.
A
total
of
145
pediatric
(
age
18
y
or
younger
)
and
157
adult
cases
of
NLPHL
were
retrieved
from
3
North
American
centers
and
tested
for
EBV
by
in
situ
hybridization
(
EBV-encoded
small
RNA
)
.
Clinical
and
pathologic
features
were
analyzed
.
Five
(
3
.
4
%
)
pediatric
and
7
(
4
.
5
%
)
adult
NLPHL
cases
contained
EBV
(
+
)
lymphocyte-predominant
(
LP
)
cells
.
Although
all
12
cases
met
the
criteria
for
diagnosis
of
NLPHL
,
atypical
features
were
present
,
including
capsular
fibrosis
,
atrophic
germinal
centers
,
and
pleomorphic
or
atypical
LP
cells
.
CD
2
0
and
OCT
-
2
were
strongly
and
diffusely
positive
in
all
except
1
case
.
However
,
PAX
5
and
CD
7
9
a
were
weak
and
/
or
variable
in
7
/
8
and
6
/
6
cases
tested
,
respectively
.
EBV
(
+
)
cases
were
more
likely
to
be
CD
30
(
+
)
(
75
%
)
compared
with
EBV
(
-
)
cases
(
25
%
)
(
P
=
0
.
0007
)
;
CD
15
was
negative
in
all
cases
.
Our
results
show
that
EBV
(
+
)
LP
cells
may
occur
in
NLPHL
.
Distinguishing
EBV
(
+
)
NLPHL
from
CHL
can
be
challenging
,
as
EBV
(
+
)
NLPHL
can
have
partial
expression
of
CD
30
and
weak
PAX
5
staining
as
well
as
pleomorphic-appearing
LP
cells
.
However
,
the
overall
appearance
and
maintenance
of
B-
cell
phenotype
,
with
strong
and
diffuse
CD
2
0
and
OCT
-
2
expression
,
support
the
diagnosis
of
NLPHL
in
these
cases
.
Diseases
Validation
Diseases presenting
"tested for ebv by in situ hybridization"
symptom
hodgkin lymphoma, classical
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