F-18 FDG-PET predicts outcomes for patients receiving total lymphoid irradiation and autologous blood stem-cell transplantation for relapsed and refractory Hodgkin lymphoma.

[hodgkin lymphoma, classical]

Total lymphoid irradiation (TLI ) followed by high -dose chemotherapy and autologous haematopoietic stem cell transplant (aHSCT ) is an effective strategy for patients with relapsed /refractory classical Hodgkin lymphoma (HL ). We report outcomes for patients with relapsed /refractory HL who received TLI followed by high -dose chemotherapy and aHSCT . Pre-transplant fludeoxyglucose positron emission tomography (FDG-PET ) studies were scored on the 5 -point Deauville scale . Of 51 patients treated with TLI and aHSCT , 59 % had primary refractory disease and 63 % had active disease at aHSCT . The 10 -year progression-free survival (PFS ) and overall survival (OS ) for all patients was 56 % and 54 %, respectively . Patients with complete response (CR ) by PET prior to aHSCT had a 5 -year PFS and OS of 85 % and 100 % compared to 52 % and 48 % for those without CR (P = 0 ·09 and P = 0 ·007 , respectively ). TLI and aHSCT yields excellent disease control and long -term survival rates for patients with relapsed /refractory HL , including those with high -risk disease features . Achievement of CR with salvage therapy is a powerful predictor of outcome .