Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Serum levels of cytokines and prevalence of autoantibodies in lymphoma patients and their prognostic value.
[hodgkin lymphoma, classical]
Recent
studies
have
shown
that
cytokines
and
autoantibodies
that
have
an
important
role
in
pathogenesis
of
lymphoma
can
be
used
as
prognostic
markers
.
In
this
study
,
we
aimed
to
determine
the
prognostic
significance
of
a
large
panel
of
serum
cytokines
and
compare
them
with
a
control
group
,
and
also
to
see
for
any
relationship
with
known
classical
prognostic
factors
,
the
frequency
of
autoantibody
positivity
and
autoimmune
phenomena
in
patients
with
untreated
non
Hodgkin
's
lymphoma
(
NHL
)
and
Hodgkin
's
lymphoma
(
HL
)
.
For
cytokine
studies
blood
samples
were
obtained
in
the
morning
after
fasting
for
at
least
8
-
12
h
.
We
used
empty
tubes
for
serum
and
EDTA-containing
tubes
for
plasma
samples
.
Blood
samples
were
then
transferred
to
laboratory
in
5
-
10
min
,
plasma
and
sera
were
separated
by
centrifugation
,
and
stored
at
-
75
?
C
until
assayed
.
Then
,
all
sera
were
warmed
to
room
temperature
.
All
the
cytokine
levels
were
studied
with
Panomics
Company
ProcartaTM
Human
Cytokine
multiplex
kits
.
In
lymphoma
patients
INF-ggr
;
was
related
with
thyroglobulin
antibody
positivity
and
IL
-
6
with
direct
Coombs
positivity
.
IL
-
6
was
the
most
important
cytokine
connected
with
lymphopenia
and
B
symptoms
in
lymphoma
patients
.
IL
-
1
β
,
INF-γ
,
IL
-
2
and
IL
-
4
were
markers
associated
with
poor
prognosis
in
HL
.
At
least
one
autoantibody
was
positive
in
50
%
of
NHL
and
HL
patients
.
At
least
one
antiphospholipid
antibody
(
APA
)
was
positive
in
26
%
of
NHL
and
38
%
of
HL
patients
.
TNF
-α
and
IL
-
6
are
poor
prognostic
factors
that
may
be
included
in
the
International
Prognostic
Index
(
IPI
)
.
To
understand
the
effects
of
autoantibodies
in
the
prognosis
of
HL
and
NHL
,
long
-term
patient
follow-up
studies
are
required
.
Diseases
Validation
Diseases presenting
"lymphoma"
symptom
adrenal incidentaloma
alpha-thalassemia
carcinoma of the gallbladder
cushing syndrome
dedifferentiated liposarcoma
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
familial hypocalciuric hypercalcemia
focal myositis
hirschsprung disease
hodgkin lymphoma, classical
kabuki syndrome
liposarcoma
locked-in syndrome
monosomy 21
oculocutaneous albinism
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
wiskott-aldrich syndrome
This symptom has already been validated