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CD68-positive tumor-associated macrophages predict unfavorable treatment outcomes in classical Hodgkin lymphoma in correlation with interim fluorodeoxyglucose-positron emission tomography assessment.
[hodgkin lymphoma, classical]
Finding
new
prognostic
factors
to
identify
patients
with
Hodgkin
lymphoma
(
HL
)
at
risk
of
treatment
resistance
or
relapse
remains
challenging
in
daily
practice
.
We
evaluated
the
relationship
between
CD
68
expression
,
interim
positron
emission
tomography
(
iPET
)
results
and
outcome
in
158
patients
with
HL
diagnosed
from
February
1995
to
July
2011
.
Immunohistochemistry
(
anti-
CD
68
)
gave
two
groups
:
low
with
≤
25
%
positive
cells
(
121
patients
)
and
high
with
>
25
%
(
37
patients
)
.
Five
-
year
overall
survival
was
higher
in
the
low
group
(
88
.
4
%
vs
.
63
.
2
%
,
p
=
0
.
0151
)
,
as
was
progression-free
survival
(
74
.
5
%
vs
.
40
.
7
%
,
p
=
0
.
0003
)
.
In
68
patients
evaluable
,
iPET
correlated
with
CD
68
:
13
/
52
patients
(
25
%
)
in
the
low
group
had
positive
iPET
as
compared
to
11
/
16
patients
(
68
%
)
in
the
high
group
(
p
=
0
.
0016
)
.
This
study
confirms
the
prognostic
value
of
CD
68
in
HL
.
We
found
a
correlation
between
CD
68
and
iPET
suggesting
potential
for
a
better
stratification
.
Diseases
Validation
Diseases presenting
"positive cells"
symptom
canavan disease
carcinoma of the gallbladder
coats disease
congenital diaphragmatic hernia
dedifferentiated liposarcoma
epidermolysis bullosa simplex
erythropoietic protoporphyria
esophageal adenocarcinoma
hodgkin lymphoma, classical
severe combined immunodeficiency
werner syndrome
x-linked adrenoleukodystrophy
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