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CD68-positive tumor-associated macrophages predict unfavorable treatment outcomes in classical Hodgkin lymphoma in correlation with interim fluorodeoxyglucose-positron emission tomography assessment.
[hodgkin lymphoma, classical]
Finding
new
prognostic
factors
to
identify
patients
with
Hodgkin
lymphoma
(
HL
)
at
risk
of
treatment
resistance
or
relapse
remains
challenging
in
daily
practice
.
We
evaluated
the
relationship
between
CD
68
expression
,
interim
positron
emission
tomography
(
iPET
)
results
and
outcome
in
158
patients
with
HL
diagnosed
from
February
1995
to
July
2011
.
Immunohistochemistry
(
anti-
CD
68
)
gave
two
groups
:
low
with
≤
25
%
positive
cells
(
121
patients
)
and
high
with
>
25
%
(
37
patients
)
.
Five
-
year
overall
survival
was
higher
in
the
low
group
(
88
.
4
%
vs
.
63
.
2
%
,
p
=
0
.
0151
)
,
as
was
progression-free
survival
(
74
.
5
%
vs
.
40
.
7
%
,
p
=
0
.
0003
)
.
In
68
patients
evaluable
,
iPET
correlated
with
CD
68
:
13
/
52
patients
(
25
%
)
in
the
low
group
had
positive
iPET
as
compared
to
11
/
16
patients
(
68
%
)
in
the
high
group
(
p
=
0
.
0016
)
.
This
study
confirms
the
prognostic
value
of
CD
68
in
HL
.
We
found
a
correlation
between
CD
68
and
iPET
suggesting
potential
for
a
better
stratification
.