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Comparison of positron emission tomography/computed tomography with classical contrast-enhanced computed tomography in the initial staging of Hodgkin lymphoma.
[hodgkin lymphoma, classical]
We
compared
initial
computed
tomography
(
CT
)
and
positron
emission
tomography
(
PET
)
/
CT
in
96
patients
with
Hodgkin
lymphoma
(
HL
)
,
assessing
the
role
of
baseline
PET
/
CT
in
stage
migration
and
treatment
selection
.
The
number
of
patients
with
stage
I
,
II
,
III
and
IV
disease
based
on
CT
versus
PET
/
CT
was
:
5
vs
.
7
,
49
vs
.
37
,
28
vs
.
22
and
14
vs
.
30
,
respectively
.
In
33
(
34
%
)
patients
,
PET
/
CT
changed
HL
stage
:
27
(
28
%
)
were
upstaged
and
six
(
6
.
3
%
)
downstaged
.
Upstaging
was
caused
by
detection
of
new
extranodal
involvements
(
47
sites
in
26
patients
)
:
bone
marrow
(
10
patients
)
,
spleen
(
five
patients
)
and
lung
(
two
patients
)
.
In
nine
patients
≥
2
further
coexisting
locations
were
detected
.
Downstaging
resulted
from
the
absence
of
fluorodeoxyglucose
(
(
18
)
F-FDG
)
uptake
in
enlarged
nodes
(
>
15
mm
)
in
the
abdomen
and
pelvis
.
PET
/
CT
modified
HL
stage
in
34
%
of
patients
leading
to
treatment
modification
in
the
majority
.
Our
results
indicate
that
PET
/
CT
should
be
mandatory
in
the
initial
staging
of
HL
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated