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Comparison of positron emission tomography/computed tomography with classical contrast-enhanced computed tomography in the initial staging of Hodgkin lymphoma.
[hodgkin lymphoma, classical]
We
compared
initial
computed
tomography
(
CT
)
and
positron
emission
tomography
(
PET
)
/
CT
in
96
patients
with
Hodgkin
lymphoma
(
HL
)
,
assessing
the
role
of
baseline
PET
/
CT
in
stage
migration
and
treatment
selection
.
The
number
of
patients
with
stage
I
,
II
,
III
and
IV
disease
based
on
CT
versus
PET
/
CT
was
:
5
vs
.
7
,
49
vs
.
37
,
28
vs
.
22
and
14
vs
.
30
,
respectively
.
In
33
(
34
%
)
patients
,
PET
/
CT
changed
HL
stage
:
27
(
28
%
)
were
upstaged
and
six
(
6
.
3
%
)
downstaged
.
Upstaging
was
caused
by
detection
of
new
extranodal
involvements
(
47
sites
in
26
patients
)
:
bone
marrow
(
10
patients
)
,
spleen
(
five
patients
)
and
lung
(
two
patients
)
.
In
nine
patients
≥
2
further
coexisting
locations
were
detected
.
Downstaging
resulted
from
the
absence
of
fluorodeoxyglucose
(
(
18
)
F-FDG
)
uptake
in
enlarged
nodes
(
>
15
mm
)
in
the
abdomen
and
pelvis
.
PET
/
CT
modified
HL
stage
in
34
%
of
patients
leading
to
treatment
modification
in
the
majority
.
Our
results
indicate
that
PET
/
CT
should
be
mandatory
in
the
initial
staging
of
HL
.
