Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Epstein-Barr virus-positive nodular lymphocyte predominant Hodgkin lymphoma.
[hodgkin lymphoma, classical]
Hodgkin
lymphoma
(
HL
)
is
classified
into
2
largely
distinct
subgroups
,
namely
nodular
lymphocyte
predominant
HL
(
NLPHL
)
and
classic
HL
(
CHL
)
.
CHL
is
further
divided
into
nodular
sclerosis
,
lymphocyte-rich
,
mixed
cellularity
(
MCCHL
)
and
lymphocyte-depleted
(
LDCHL
)
subtypes
.
In
industrialized
nations
,
Epstein-
Barr
virus
(
EBV
)
has
been
associated
with
all
types
of
CHL
,
especially
the
MCCHL
and
LDCHL
subtypes
,
but
is
rare
in
NLPHL
.
We
report
8
cases
of
EBV-
positive
NLPHL
occurring
in
patients
in
the
United
States
.
All
8
patients
have
no
history
of
immunosuppression
and
presented
with
localized
or
systemic
lymphadenopathy
.
Histologically
,
6
cases
had
a
vaguely
nodular
pattern
and
2
cases
had
a
nodular
and
diffuse
pattern
.
In
all
cases
,
lymphocyte
predominant
(
LP
)
cells
were
observed
in
a
background
of
small
lymphocytes
and
histiocytes
.
Immunohistochemical
analysis
showed
that
the
LP
cells
in
all
cases
were
positive
for
CD
2
0
,
CD
7
9
a
,
PAX
5
,
OCT
2
,
and
CD
4
5
and
were
negative
for
CD
15
.
CD
30
was
expressed
variably
in
7
cases
.
EBV
encoded
RNA
was
present
in
all
LP
cells
in
5
cases
and
in
a
subset
of
LP
cells
in
3
cases
.
One
patient
was
treated
with
radiation
therapy
and
7
patients
received
chemotherapy
,
including
4
of
7
patients
who
underwent
autologous
stem
cell
transplantation
.
EBV
infection
is
a
rare
primary
or
secondary
event
in
NLPHL
that
correlates
with
poorer
prognosis
and
often
requires
more
aggressive
therapy
.
The
variable
expression
of
CD
30
in
most
of
these
cases
could
be
the
result
of
EBV
infection
.
Diseases
Validation
Diseases presenting
"secondary event"
symptom
hodgkin lymphoma, classical
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom