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Tumor microenvironment and RIG-I signaling molecules in Epstein Barr virus-positive and -negative classical Hodgkin lymphoma of the elderly.
[hodgkin lymphoma, classical]
Classical
Hodgkin
lymphoma
(
CHL
)
is
a
B-
cell
neoplasm
characterized
by
Hodgkin
and
Reed
-
Sternberg
(
HRS
)
cells
.
Its
prevalence
exhibits
a
bimodal
pattern
of
peaking
in
young
adults
and
the
elderly
.
There
is
an
association
with
Epstein-
Barr
virus
(
EBV
)
infection
in
about
50
%
of
cases
of
CHL
of
the
elderly
,
and
the
outcome
of
these
patients
is
unfavorable
.
It
is
not
well
known
how
the
latent
infection
of
EBV
is
involved
in
the
pathophysiology
of
CHL
of
the
elderly
.
To
address
this
issue
,
we
examined
the
tumor
microenvironment
(
TME
)
and
the
expression
of
molecules
related
to
EBV
infection
in
HRS
cells
in
10
EBV-
positive
CHL
and
7
EBV-negative
CHL
patients
older
than
50
years
.
In
EBV-
positive
CHL
,
we
found
an
increased
population
of
FOXP
3
(
+
)
cells
,
while
that
of
granzyme
B
(
+
)
cells
was
reduced
,
compared
with
those
in
EBV-negative
CHL
.
The
expression
of
inhibitory
chemokine
CCL
20
was
increased
in
EBV-
positive
HRS
cells
compared
with
that
in
EBV-negative
HRS
cells
.
In
addition
,
despite
increased
expression
of
a
pattern
recognition
receptor
,
RIG-
I
,
in
intracellular
innate
immunity
,
there
was
no
evidence
of
interferon
regulatory
factor
3
activation
or
interferon-ß
induction
in
EBV-
positive
HRS
cells
in
CHL
of
the
elderly
.
The
disease
recurred
frequently
(
50
%
)
in
EBV-
positive
CHL
.
The
current
study
thus
suggests
the
possibility
that
the
latent
infection
of
EBV
alters
the
expression
of
chemokines
and
the
innate
immunity
response
in
HRS
cells
and
modulates
TME
to
an
immunosuppressive
state
,
which
may
account
for
the
unfavorable
disease
course
in
CHL
of
the
elderly
.
Diseases
Validation
Diseases presenting
"increased expression of a pattern recognition receptor"
symptom
hodgkin lymphoma, classical
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