Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Refractory Classical Hodgkin Lymphoma Presenting with Atypical Cutaneous Involvement and Diagnosis of ZZ Phenotype Alpha-1 Antitrypsin Deficiency.
[hodgkin lymphoma, classical]
Cutaneous
Hodgkin
lymphoma
is
a
rare
condition
.
Specific
neoplastic
involvement
can
be
primary
(
confined
to
the
skin
)
or
secondary
to
systemic
involvement
(
metastatic
)
.
Cutaneous
involvement
by
HL
usually
occurs
late
in
the
course
and
is
associated
with
poor
prognosis
;
however
in
some
cases
it
can
exhibit
indolent
behavior
.
Skin
involvement
with
nonspecific
cutaneous
findings
may
represent
a
paraneoplastic
syndrome
.
We
describe
a
case
of
46
-
year
-old
white
male
patient
presented
with
rash
and
lymphadenopathy
which
led
to
the
diagnosis
of
stage
IVE
mixed
cellularity
classical
Hodgkin
lymphoma
with
skin
involvement
.
His
disease
was
refractory
to
multiple
lines
of
chemotherapy
including
(
1
)
AVD
(
doxorubicin
/
bleomycin
/
dacarbazine
)
,
(
2
)
brentuximab
,
and
(
3
)
bendamustine
,
he
later
achieved
complete
remission
with
(
4
)
GCD
(
gemcitabine
/
carboplatin
/
dexamethasone
)
salvage
regimen
.
Bleomycin
was
not
given
secondary
to
poor
pulmonary
function
tests
.
His
treatment
was
complicated
after
AVD
with
multiple
pneumothoraces
which
unmasked
the
diagnosis
of
ZZ
phenotype
alpha-
1
antitrypsin
(
ATT
)
deficiency
.
Simultaneous
existence
of
Hodgkin
lymphoma
and
ATT
is
rarely
reported
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated