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Performance of FDG PET/CT at initial diagnosis in a rare lymphoma: nodular lymphocyte-predominant Hodgkin lymphoma.
[hodgkin lymphoma, classical]
Nodular
lymphocyte-predominant
Hodgkin
lymphoma
(
NLPHL
)
is
a
rare
Hodgkin
lymphoma
distinguished
from
classical
Hodgkin
lymphoma
(
cHL
)
by
the
nature
of
the
neoplastic
cells
which
express
B-
cell
markers
.
We
wanted
to
determine
the
diagnostic
performance
of
FDG
PET
/
CT
in
initial
assessment
and
its
therapeutic
impact
on
staging
.
We
retrospectively
studied
a
population
of
35
patients
with
NLPHL
(
8
previously
treated
for
NLHPL
,
27
untreated
)
.
All
patients
underwent
an
initial
staging
by
pretherapeutic
FDG
PET
/
CT
.
The
impact
on
initial
stage
or
relapse
stage
was
assessed
by
an
independent
physician
.
In
a
per
-patient
analysis
,
the
sensitivity
of
the
pretherapeutic
FDG
PET
/
CT
was
100
%
.
In
a
per
-site
analysis
,
the
sensitivity
,
specificity
,
positive
predictive
value
,
negative
predictive
value
and
accuracy
of
pretherapeutic
FDG
PET
/
CT
were
100
%
,
99
%
,
97
%
,
100
%
and
99
%
,
respectively
.
Pretherapeutic
FDG
PET
/
CT
led
to
a
change
in
the
initial
stage
/
relapse
stage
in
12
of
the
35
patients
(
34
%
)
.
In
contrast
to
previous
results
established
without
FDG
PET
/
CT
,
20
%
of
patient
had
osteomedullary
lesions
.
Pretherapeutic
FDG
PET
/
CT
has
excellent
performance
for
initial
staging
or
relapse
staging
of
NLPHL
.
Diseases
Validation
Diseases presenting
"positive predictive value"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
carcinoma of the gallbladder
cholangiocarcinoma
congenital adrenal hyperplasia
congenital diaphragmatic hernia
congenital toxoplasmosis
cushing syndrome
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
heparin-induced thrombocytopenia
hodgkin lymphoma, classical
phenylketonuria
thoracic outlet syndrome
typhoid
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