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Performance of FDG PET/CT at initial diagnosis in a rare lymphoma: nodular lymphocyte-predominant Hodgkin lymphoma.
[hodgkin lymphoma, classical]
Nodular
lymphocyte-predominant
Hodgkin
lymphoma
(
NLPHL
)
is
a
rare
Hodgkin
lymphoma
distinguished
from
classical
Hodgkin
lymphoma
(
cHL
)
by
the
nature
of
the
neoplastic
cells
which
express
B-
cell
markers
.
We
wanted
to
determine
the
diagnostic
performance
of
FDG
PET
/
CT
in
initial
assessment
and
its
therapeutic
impact
on
staging
.
We
retrospectively
studied
a
population
of
35
patients
with
NLPHL
(
8
previously
treated
for
NLHPL
,
27
untreated
)
.
All
patients
underwent
an
initial
staging
by
pretherapeutic
FDG
PET
/
CT
.
The
impact
on
initial
stage
or
relapse
stage
was
assessed
by
an
independent
physician
.
In
a
per
-patient
analysis
,
the
sensitivity
of
the
pretherapeutic
FDG
PET
/
CT
was
100
%
.
In
a
per
-site
analysis
,
the
sensitivity
,
specificity
,
positive
predictive
value
,
negative
predictive
value
and
accuracy
of
pretherapeutic
FDG
PET
/
CT
were
100
%
,
99
%
,
97
%
,
100
%
and
99
%
,
respectively
.
Pretherapeutic
FDG
PET
/
CT
led
to
a
change
in
the
initial
stage
/
relapse
stage
in
12
of
the
35
patients
(
34
%
)
.
In
contrast
to
previous
results
established
without
FDG
PET
/
CT
,
20
%
of
patient
had
osteomedullary
lesions
.
Pretherapeutic
FDG
PET
/
CT
has
excellent
performance
for
initial
staging
or
relapse
staging
of
NLPHL
.
Diseases
Validation
Diseases presenting
"stage/relapse stage"
symptom
hodgkin lymphoma, classical
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