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[Grey zone lymphoma with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: clinicopathologic characterization of 16 cases showing different patterns].
[hodgkin lymphoma, classical]
To
profile
the
clinicopathologic
features
of
a
series
of
grey
zone
lymphoma
(
GZL
)
cases
with
hybrid
features
of
diffuse
large
B-
cell
lymphoma
(
DLBCL
)
and
classical
Hodgkin
lymphoma
(
CHL
)
,
with
a
purpose
to
gain
an
in
-depth
understanding
of
the
borderline
B-
cell
neoplasm
.
The
clinical
,
morphologic
and
immunophenotyical
characteristics
of
16
cases
were
retrospectively
analyzed
.
The
patients
were
mostly
male
adults
,
with
a
male
to
female
ratio
of
1
.
7
:
1
.
0
and
a
mean
age
of
40
.
2
years
.
Eight
patients
presented
with
peripheral
nodal
lesions
and
five
cases
with
mediastinal
involvement
.
Histologically
and
immunophenotypically
,
the
16
cases
were
classified
into
three
sub-categories
.
In
4
cases
,
the
morphologic
features
resembled
CHL
more
closely
,
but
the
neoplastic
cells
showed
uniform
and
intense
positive
staining
of
CD
2
0
(
pattern
1
)
.
Although
the
initial
impression
of
the
other
8
cases
was
that
of
DLBCL
,
the
expression
levels
of
CD
2
0
and
PAX
5
were
variable
,
and
CD
30
or
CD
15
was
positive
(
pattern
2
)
.
A
characteristic
feature
of
pattern
3
,
observed
in
the
remaining
4
cases
,
demonstrated
a
broad
spectrum
of
morphology
with
hybrid
features
of
both
CHL
and
DLBCL
.
The
neoplastic
cells
in
pattern
3
were
positive
for
CD
2
0
,
CD
30
and
CD
15
.
EBV-LMP
1
was
detected
in
6
of
the
11
tested
cases
.
Clinically
,
most
patients
with
GZL
seemed
insensitive
to
immuno-chemotherapy
of
the
R-CHOP
regimen
.
T
he
diagnostic
criteria
for
GZL
with
features
intermediate
between
DLBCL
and
CHL
is
proposed
by
the
three
histologic
patterns
commonly
seen
in
these
lesions
.
Cases
presented
with
peripheral
lesions
might
differ
from
those
with
mediastinal
presentation
pathologically
.
At
current
time
,
there
is
no
effective
treatment
for
these
borderline
B-
cell
lymphomas
and
the
prognosis
is
poor
.
Diseases
Validation
Diseases presenting
"with a male to female ratio of 1"
symptom
hodgkin lymphoma, classical
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