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Flow cytometry of ALK-negative anaplastic large cell lymphoma of breast implant-associated effusion and capsular tissue.
[hodgkin lymphoma, classical]
Anaplastic
large
cell
lymphoma
(
ALCL
)
of
the
breast
capsule
is
a
rare
lymphoma
involving
capsular
tissues
and
/
or
effusions
associated
with
breast
implants
.
While
several
studies
have
detailed
the
histological
and
immunohistochemical
(
IHC
)
features
of
these
tumors
,
no
study
has
yet
described
flow
cytometry
features
of
the
neoplastic
cells
of
this
entity
.
Here
,
we
report
two
cases
from
our
institution
in
which
multi-parametric
flow
cytometry
was
performed
.
The
immunophenotype
of
ALCL
in
association
with
breast
implant
was
evaluated
by
flow
cytometry
.
We
show
that
much
like
CD
30
+
tumor
cells
of
classical
Hodgkin
lymphoma
(
CHL
)
and
ALCL
of
non-
breast
implant
tumors
,
the
neoplastic
cells
of
this
entity
can
be
readily
identified
by
flow
cytometry
.
The
neoplastic
cells
of
both
cases
were
largely
devoid
of
T
-
cell
antigens
,
but
had
expression
of
weak
CD
15
,
strong
CD
30
,
and
expression
of
CD
40
.
These
results
are
correlated
with
routine
morphologic
and
IHC
analysis
,
supporting
the
flow
cytometry
immunophenotype
.
Flow
cytometry
can
aid
in
the
diagnostic
evaluation
of
effusions
or
tissue
samples
in
association
with
breast
implant
/
prostheses
.
©
2014
International
Clinical
Cytometry
Society
.
Diseases
Validation
Diseases presenting
"breast capsule"
symptom
hodgkin lymphoma, classical
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