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Prognostic significance of CD20 expression and Epstein-Barr virus (EBV) association in classical Hodgkin lymphoma in Japan: a clinicopathologic study.
[hodgkin lymphoma, classical]
To
investigate
the
clinicopathological
significance
of
CD
2
0
expression
and
Epstein-
Barr
virus
(
EBV
)
association
in
Hodgkin
and
Reed
-
Sterberg
cells
of
classical
Hodgkin
lymphoma
(
CHL
)
,
CD
2
0
expression
and
EBV
positivity
(
by
EBER
in
situ
hybridization
)
were
investigated
in
389
CHL
patients
in
Japan
.
They
included
74
CD
2
0
-
positive
cases
(
19
%
)
and
315
CD
2
0
-
negative
cases
(
81
%
)
.
CD
2
0
-
positive
cases
showed
significantly
older
age
at
onset
(
P
=
0
.
018
)
and
higher
association
with
EBV
(
P
=
0
.
002
)
.
Multivariate
analysis
identified
EBV-positivity
(
but
not
CD
2
0
-
positivity
)
,
presence
of
B
symptoms
,
thrombocytopenia
,
elevated
serum
lactate
dehydrogenase
and
performance
status
>
1
as
poor
prognostic
factors
for
overall
survival
(
OS
)
.
We
constructed
a
new
prognostic
model
with
these
five
factors
classifying
patients
into
three
groups
:
low
risk
,
0
-
1
adverse
factor
;
intermediate
risk
,
2
-
3
factors
;
high
risk
,
4
-
5
factors
.
This
prognostic
model
could
stratify
the
prognosis
of
CHL
patients
(
P
<
0
.
0001
)
.
For
144
patients
(
58
%
)
classified
into
the
low
-risk
group
,
the
5
-
year
OS
was
91
%
.
For
92
patients
(
37
%
)
in
the
intermediate
group
,
the
5
-
year
OS
was
66
%
;
for
11
patients
(
5
%
)
in
the
high
-risk
group
,
the
5
-
year
OS
was
36
%
.
In
conclusion
,
EBV
is
identified
as
an
independent
poor
prognostic
factor
for
CHL
patients
.
Therefore
,
examination
of
EBV
association
in
CHL
is
recommended
as
routine
pathologic
practice
especially
in
countries
where
EBV
infection
prevails
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated