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A random Abstract
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Role of vascular endothelial growth factor C in classical c.
[hodgkin lymphoma, classical]
ABSTRACT
We
performed
three
different
studies
to
obtain
additional
data
on
the
biological
and
prognostic
role
of
VEGFC
in
classical
Hodgkin
's
lymphoma
(
cHL
)
:
1
)
serum
VEGFC
levels
were
measured
by
ELISA
in
80
patients
;
2
)
immunohistochemical
VEGFC
expression
in
tumor
tissue
was
evaluated
using
a
case-control
study
in
62
patients
;
3
)
gene
expression
of
VEGFC
was
investigated
"
in
vitro
"
in
six
cHL
cell
lines
,
and
was
compared
with
expression
in
inflammatory
lymph
nodes
.
Higher
serum
VEGFC
levels
were
found
in
patients
with
cHL
than
in
healthy
volunteers
(
median
,
7675
versus
1358
pg
/
ml
,
p
<
0
.
001
)
and
high
VEGFC
expression
in
tissue
predicted
a
worse
progression-free
survival
at
7
years
(
41
%
versus
91
%
,
p
<
0
.
0001
)
.
VEGFC
expression
in
all
Hodgkin
's
lymphoma
cell
lines
was
higher
than
the
mean
expression
level
in
inflammatory
lymph
nodes
.
Our
data
suggest
that
Hodgkin
and
Reed
-
Sternberg
cells
produce
VEGFC
,
and
VEGFC
expression
could
be
a
novel
prognostic
factor
in
cHL
.
