Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Primary cutaneous follicle center lymphoma with Hodgkin and Reed-Sternberg-like cells: a new histopathologic variant.
[hodgkin lymphoma, classical]
Primary
cutaneous
follicle
center
lymphoma
(
PCFCL
)
is
the
most
frequent
cutaneous
B-
cell
lymphoma
.
A
62
-
year
-old
man
presented
with
a
solitary
indolent
subcutaneous
nodule
for
3
years
duration
,
without
other
abnormalities
.
Histological
examination
showed
lymphoproliferation
with
a
nodular
growth
pattern
characterized
by
fibrous
collagen
bands
surrounding
nodules
.
The
nodules
were
composed
of
medium-sized
centrocytes
admixed
with
many
large
multilobulated
and
lacunar
cells
without
eosinophils
or
granulomatous
aspect
.
Hodgkin-like
cells
were
CD
30
+
,
CD
15
+
,
PAX
5
+
,
OCT
2
+
,
BOB
1
+
,
MUM
1
+
,
Ki
67
+
,
Bcl
6
+
and
focally
CD
2
0
+
and
EMA-
,
CD
7
9
a-
,
Bcl
2
-
and
CD
10
-
.
The
medium-sized
cells
were
CD
2
0
+
,
CD
7
9
a
+
,
Bcl
2
+
,
Bcl
6
+
and
CD
10
+
,
enmeshed
in
a
network
of
CD
2
1
-
positive
follicular
dendritic
cells
.
Epstein-
Barr
virus
detection
was
negative
.
Interphase
fluorescence
in
situ
hybridization
showed
the
absence
of
BCL
2
or
BCL
6
rearrangement
.
In
such
a
case
,
the
presence
of
Hodgkin-like
cells
intermixed
with
the
tumor
population
may
result
in
a
pitfall
diagnosis
of
classical
Hodgkin
lymphoma
(
CHL
)
.
Differential
diagnoses
to
be
ruled
out
are
secondary
or
primary
skin
localization
of
rather
CHL
,
or
systemic
follicular
lymphoma
.
Several
clinical
,
radiological
,
histological
,
immunohistochemical
and
molecular
arguments
indicated
the
diagnosis
of
PCFCL
.
To
our
knowledge
,
this
is
the
first
report
of
PCFCL
with
Hodgkin-like
cells
.
Diseases
Validation
Diseases presenting
"skin localization"
symptom
hodgkin lymphoma, classical
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom