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Clinical characteristics of 26 patients with primary extranodal Hodgkin lymphoma.
[hodgkin lymphoma, classical]
Most
Hodgkin
lymphoma
(
HL
)
patients
present
with
disease
in
nodal
regions
.
However
,
in
a
small
subset
,
disease
develops
extranodal
sites
primarily
,
such
as
lung
and
liver
.
This
study
aims
to
identify
the
characteristics
and
outcomes
of
patients
with
primary
extranodal
HL
.
A
retrospective
analysis
of
patients
with
HL
from
1998
to
2012
was
enrolled
.
We
selected
26
HL
patients
with
primary
extranodal
involvement
from
251
previously
untreated
HL
patients
.
All
data
analyses
were
performed
with
SPSS
software
version
17
.
0
and
GraphPad
Prism
5
.
We
identified
26
patients
with
primary
extranodal
HL
.
Results
in
the
series
of
young
patients
,
male
predominated
.
Pathologically
,
the
major
pathologic
types
were
nodular
sclerosis
classical
HL
(
NSCHL
,
46
.
2
%
)
and
mixed
cellularity
classical
HL
(
MCCHL
,
38
.
5
%
)
.
Thirteen
patients
had
early
stage
(
I
or
II
stage
)
.
The
most
commonly
primarily
extranodal
sites
were
the
lung
and
the
stomach
and
intestine
,
followed
by
the
liver
and
bones
.
Fifteen
of
26
received
chemotherapy
alone
and
11
received
combination
therapy
.
Finally
,
primary
extranodal
HLs
in
our
study
have
a
favorable
survival
.
Furthermore
,
there
was
no
significant
association
between
the
international
prognostic
score
(
IPS
)
and
survival
in
patients
with
extranodal
HL
.
Our
retrospective
data
in
part
reflect
clinical
characteristics
of
primary
extranodal
HL
in
China
,
and
form
the
basis
for
further
concerning
researches
.
Diseases
Validation
Diseases presenting
"mixed cellularity"
symptom
hodgkin lymphoma, classical
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