Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Nodular lymphocyte-predominant Hodgkin lymphoma in children: clinical course, biology, and management.
[hodgkin lymphoma, classical]
Nodular
lymphocyte
predominant
Hodgkin
disease
(
NLPHL
)
differs
clearly
from
classical
Hodgkin
lymphoma
(
cHL
)
by
clinical
presentation
and
more
favorable
outcome
.
Patients
often
present
with
early
stage
IA
or
IIA
.
Extranodal
disease
and
B-
symptoms
are
uncommon
.
Histologically
,
NLPHL
is
characterized
by
the
presence
of
atypical
"
lymphocyte
predominant
cells
"
(
LP
cells
)
or
"
pop-corn
"
cells
in
a
non-neoplastic
and
reactionnal
nodular
background
of
small
mature
B-
lymphocytes
.
LP
cells
are
negative
for
CD
30
and
positive
for
CD
2
0
,
BCL
6
and
EMA
(
in
half
of
the
cases
)
.
FDG-PET
plays
an
important
role
in
evaluation
of
cHL
and
NLPHL
for
staging
,
therapy
assessment
and
relapse
.
Historically
,
patients
with
NLPHL
have
been
treated
like
patients
with
cHL
,
but
their
very
favorable
prognosis
and
the
risk
of
late
complications
of
chemotherapy
and
/
or
radiotherapy
have
led
to
a
de
-escalation
in
recent
years
.
Patients
with
early
stage
could
be
treated
by
surgical
adenectomy
alone
or
associated
with
not
intensive
chemotherapy
.
Currently
,
there
is
no
consensus
regarding
to
the
optimal
treatment
of
patients
with
advanced
stage
.
Rituximab
used
as
monotherapy
or
in
association
with
chemotherapy
has
achieved
complete
or
partial
responses
.
The
outcome
of
NLPHL
is
singular
by
the
frequent
occurrence
of
late
relapses
and
the
risk
of
transformation
into
aggressive
B
lymphoma
justifying
an
extended
follow-up
.
Further
prospective
studies
are
needed
to
optimize
treatment
of
these
advanced
and
recurrent
forms
.
Diseases
Validation
Diseases presenting
"frequent occurrence"
symptom
hodgkin lymphoma, classical
x-linked adrenoleukodystrophy
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom