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Intrafollicular classical Hodgkin lymphoma mimicking nodular lymphocyte predominant Hodgkin lymphoma: A report of two cases.
[hodgkin lymphoma, classical]
We
here
report
on
two
rare
cases
of
intrafollicular
classical
Hodgkin
lymphoma
(
CHL
)
.
Case
1
was
a
34
-
year
-old
man
who
underwent
left
supraclavicular
lymph
node
biopsy
.
Case
2
was
a
28
-
year
-old
woman
who
underwent
surgical
resection
of
an
anterior
mediastinal
mass
.
The
histology
and
microenvironment
of
both
specimens
resembled
those
of
nodular
lymphocyte
predominant
Hodgkin
lymphoma
.
Nodular
architecture
was
observed
,
which
comprised
normal-appearing
small
lymphocytes
and
scattered
lymphocyte
predominant
(
LP
)
-
like
cells
.
CD
2
3
(
+
)
follicular
dendritic
cell
meshworks
were
present
in
the
nodules
,
surrounded
by
a
mantle
zone
containing
IgD
(
+
)
B
cells
.
The
LP
-like
cells
were
ringed
by
CD
3
(
+
)
and
PD-
1
(
+
)
T
cells
,
and
numerous
CD
2
0
(
+
)
B
cells
were
present
in
the
background
.
However
,
the
immunophenotypes
of
the
LP
-like
cells
resembled
those
of
Hodgkin
/
Reed
-
Sternberg
cells
of
CHL
;
they
were
positive
for
CD
15
,
CD
30
,
and
PAX
5
,
and
negative
for
CD
2
0
,
Bcl
6
,
Oct
2
,
and
Bob
1
.
These
histopathological
findings
indicate
that
CHL
can
be
derived
from
the
germinal
center
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated