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Intrafollicular classical Hodgkin lymphoma mimicking nodular lymphocyte predominant Hodgkin lymphoma: A report of two cases.
[hodgkin lymphoma, classical]
We
here
report
on
two
rare
cases
of
intrafollicular
classical
Hodgkin
lymphoma
(
CHL
)
.
Case
1
was
a
34
-
year
-old
man
who
underwent
left
supraclavicular
lymph
node
biopsy
.
Case
2
was
a
28
-
year
-old
woman
who
underwent
surgical
resection
of
an
anterior
mediastinal
mass
.
The
histology
and
microenvironment
of
both
specimens
resembled
those
of
nodular
lymphocyte
predominant
Hodgkin
lymphoma
.
Nodular
architecture
was
observed
,
which
comprised
normal-appearing
small
lymphocytes
and
scattered
lymphocyte
predominant
(
LP
)
-
like
cells
.
CD
2
3
(
+
)
follicular
dendritic
cell
meshworks
were
present
in
the
nodules
,
surrounded
by
a
mantle
zone
containing
IgD
(
+
)
B
cells
.
The
LP
-like
cells
were
ringed
by
CD
3
(
+
)
and
PD-
1
(
+
)
T
cells
,
and
numerous
CD
2
0
(
+
)
B
cells
were
present
in
the
background
.
However
,
the
immunophenotypes
of
the
LP
-like
cells
resembled
those
of
Hodgkin
/
Reed
-
Sternberg
cells
of
CHL
;
they
were
positive
for
CD
15
,
CD
30
,
and
PAX
5
,
and
negative
for
CD
2
0
,
Bcl
6
,
Oct
2
,
and
Bob
1
.
These
histopathological
findings
indicate
that
CHL
can
be
derived
from
the
germinal
center
.
Diseases
Validation
Diseases presenting
"nodular lymphocyte predominant"
symptom
hodgkin lymphoma, classical
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