Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Granulocyte-colony stimulating factor: a new player for the enteric nervous system.
[hirschsprung disease]
The
enteric
nervous
system
(
ENS
)
controls
and
modulates
gut
motility
and
responds
to
food
intake
and
to
internal
and
external
stimuli
such
as
toxins
or
inflammation
.
Its
plasticity
is
maintained
throughout
life
by
neural
progenitor
cells
within
the
enteric
stem
cell
niche
.
Granulocyte-colony
stimulating
factor
(
G-CSF
)
is
known
to
act
not
only
on
cells
of
the
immune
system
but
also
on
neurons
and
neural
progenitors
in
the
central
nervous
system
(
CNS
)
.
Here
,
we
demonstrate
,
for
the
first
time
,
that
G-CSF
receptor
is
present
on
enteric
neurons
and
progenitors
and
that
G-CSF
plays
a
role
in
the
expansion
and
differentiation
of
enteric
neural
progenitor
cells
.
Cultured
mouse
ENS-neurospheres
show
increased
expansion
with
increased
G-CSF
concentrations
,
in
contrast
to
CNS-derived
spheres
.
In
cultures
from
differentiated
ENS-
and
CNS-neurospheres
,
neurite
outgrowth
density
is
enhanced
depending
on
the
amount
of
G-CSF
in
the
culture
.
G-CSF
might
be
an
important
factor
in
the
regeneration
and
differentiation
of
the
ENS
and
might
be
a
useful
tool
for
the
investigation
and
treatment
of
ENS
disorders
.
Diseases
Validation
Diseases presenting
"central nervous system"
symptom
22q11.2 deletion syndrome
adrenomyeloneuropathy
alexander disease
aniridia
aromatase deficiency
canavan disease
child syndrome
classical phenylketonuria
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
fabry disease
gm1 gangliosidosis
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
kabuki syndrome
kallmann syndrome
kindler syndrome
krabbe disease
lamellar ichthyosis
legionellosis
liposarcoma
malignant atrophic papulosis
monosomy 21
neonatal adrenoleukodystrophy
phenylketonuria
proteus syndrome
scrub typhus
severe combined immunodeficiency
sneddon syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom