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Does calretinin immunohistochemistry reduce inconclusive diagnosis in rectal biopsies for Hirschsprung disease?
[hirschsprung disease]
Many
difficulties
occur
during
the
evaluation
of
rectal
biopsies
for
the
diagnosis
of
Hirschsprung
disease
.
We
investigated
whether
the
introduction
of
calretinin
(
CR
)
immunohistochemistry
in
a
diagnostic
panel
could
decrease
the
rate
of
inconclusive
results
.
Data
from
82
patients
undergoing
rectal
biopsies
before
and
after
CR
introduction
were
analyzed
.
Inconclusive
results
were
obtained
in
17
of
45
rectal
biopsies
(
37
.
8
%
)
in
the
series
of
cases
before
CR
introduction
and
in
5
of
42
rectal
biopsies
(
11
.
9
%
)
in
the
series
of
cases
after
CR
(
P
<
0
.
006
)
.
The
inclusion
of
CR
in
the
histopathologic
panel
may
improve
the
diagnostic
accuracy
of
Hirschsprung
disease
.