Rare Diseases Symptoms Automatic Extraction
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Mutant and native human beta-amyloid precursor proteins in transgenic mouse brain.
[hereditary cerebral hemorrhage with amyloidosis]
Human
beta
-amyloid
precursor
protein
(
beta
APP
)
has
been
targeted
to
transgenic
neurons
using
synapsin
I
promoter-based
chimeric
transgenes
.
Native
human
beta
APP
was
introduced
as
well
as
beta
APP
containing
mutations
genetically
linked
to
familial
Alzheimer
's
disease
(
AD
)
and
to
hereditary
cerebral
hemorrhage
with
amyloidosis
-
Dutch
type
.
In
mouse
brain
,
human
beta
APP
RNA
was
up
to
60
%
as
abundant
as
total
endogenous
beta
APP
RNA
.
Human
beta
APP
gene
expression
was
most
abundant
in
the
CA
subfields
of
the
hippocampus
and
in
the
piriform
cortex
.
Correct
processing
of
human
beta
APP
at
the
beta
-secretase
cleavage
site
was
demonstrated
in
transgenic
mouse
brains
.
Despite
a
40
%
increase
in
total
beta
APP
immunoreactivity
in
lines
expressing
mutant
human
beta
APP
,
no
evidence
of
amyloid
deposition
was
found
in
brains
of
mice
up
to
14
months
in
age
.
Higher
levels
of
mutant
human
beta
APP
,
increased
age
,
or
other
factors
may
be
necessary
to
elicit
beta
-amyloid-related
neuropathologies
in
the
rodent
brain
.